Publicações
2023
Construction, Expression, and Evaluation of the Naturally Acquired Humoral Immune Response against Plasmodium vivax RMC-1, a Multistage Chimeric Protein.
Matos, ADS; Soares, IF; Baptista BDO; De Souza HAS; Chaves LB; Perce-Da-Silva, DS; Riccio, EKP; Albrecht, L; Totino, PRR; Rodrigues-Da-Silva RN; Daniel-Ribeiro CT; Pratt-Riccio, LR; Da Costa Lima-Junior, J. Construction, Expression, and Evaluation of the Naturally Acquired Humoral Immune Response against Plasmodium vivax RMC-1, a Multistage Chimeric Protein. Int J Mol Sci 2023 Jul 18;24(14):11571. doi: 10.3390/ijms241411571.
Plasmodium vivax transcriptomics: What is new?
Ferraboli JW; Da Veiga GTS; Albrecht L. Plasmodium vivax transcriptomics: What is new? Exp Biol Med (Maywood). 2023 Oct;248(19):1645-1656. doi: 10.1177/15353702231198070. Epub 2023 Oct 3.
A Unique Deacetylase of Toxoplasma Apicoplast.
Fragoso, MSI; De Siqueira, CM; Vitorino, FNL; Vieira, AZ; Martins-Duarte, ÉS; Faoro, H; Da Cunha, JPC; Ávila, AR; Nardelli, SC. TgKDAC4: A Unique Deacetylase of Toxoplasma Apicoplast. Microorganisms, 2023.
Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis.
Dos Santos, DA; Souza, HFS; Silber, AM; Souza, TDACBD ; Ávila, AR. Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis. Frontiers in Cellular and Infection Microbiology, 2023.
Offering technologies for innovation: strategies and challenges.
Goebel, K; Losekann, SD ; Polla, PTB; Montenegro, KBM; Ávila, AR. Offering technologies for innovation: strategies and challenges. Innovation & Management Review, , 2023.
Modulation of Virulence Factors during Trypanosoma cruzi Differentiation.
Oliveira, C; Holetz, FB ; Alves, LR ; Ávila, AR. Modulation of Virulence Factors during Trypanosoma cruzi Differentiation. PATHOGENS, 2023.
Plasmodium vivax vaccine: What is the best way to go?.
Veiga GTS da, Moriggi MR, Vettorazzi JF, Müller-Santos M, Albrecht L . Plasmodium vivax vaccine: What is the best way to go?. Frontiers in Immunology , v. 13, p. 1, 2023.
Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
Alvarez LCS, Barbosa VC, Lizcano OV, Baia Da Silva DC, Santana RAG, Fabbri C, Pimenta PFP, Monteiro MM, Albrecht L, Guimarães De Lacerda MV, Costa, FTM, Lopes, SCP . Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis. Frontiers in Cellular and Infection Microbiology, v. 13, p. 1, 2023.
Modulation of Virulence Factors during Trypanosoma cruzi Differentiation
Oliveira C ; Holetz FB, Alves LR, Ávila AR. Modulation of Virulence Factors during Trypanosoma cruzi Differentiation. PATHOGENS, v. 12, p. 32, 2023.
2022
New advances in knowledge of the parasite-host relationship during malarial infection. Frontiers in Immunology
Albrecht L, Boscardin SB, Scopel KK. Editorial: New advances in knowledge of the parasite-host relationship during malarial infection. Frontiers in Immunology, v. 13, p. 1, 2022.
Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression.
Nardelli SC, Silmon de Monerri NC, Vanagas L, Wang X, Tampaki Z, Sullivan WJ Jr, Angel SO, Kim K. Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression. BMC Genomics. 2022 Feb 14;23(1):128. doi: 10.1186/s12864-022-08338-6.
Targeting HDACs of apicomplexans: structural insights for a better treatment. Parasitology
de Siqueira CM, Fragoso MSI, Severo VR, Biembengut IV, Nardelli SC, de Souza TACB. Targeting HDACs of apicomplexans: structural insights for a better treatment. Parasitology. 2022 Mar 31:1-37. doi: 10.1017/S0031182022000427.
Proteomics uncovers novel components of an interactive protein network supporting RNA export in trypanosomes.
Inoue, Alexandre Haruo ; Domingues, Patricia Ferreira ; Serpeloni, Mariana ; Hiraiwa,priscila Mazzocchi ; Vidal, Newton Medeiros ; Butterfield, Erin R. ; Del Pino, Ricardo Canavate ; Ludwig, Adriana ; Boehm, Cordula ; Field, Mark C. ; Ávila, Andréa Rodrigues . Proteomics uncovers novel components of an interactive protein network supporting RNA export in trypanosomes. MOLECULAR & CELLULAR PROTEOMICS. 2022. doi: 10.1016/j.mcpro.2022.100208.
2021
Capítulo de Livro: Toxoplasma gondii: Biology and Role in Health and Disease Chapter 6: Epigenetic Regulation Affects Essential Mechanisms in Toxoplasma Gondii
Siqueira, Caroline de Moraes; Schwartz, Julia; Fragoso, Mariana Sayuri Ishikawa; Severo, Vanessa Rossini and Nardelli, Sheila Cristina – 1ed. 1ed.Hauppauge: Nova Science Publishers, Inc., 2021, v. 1, p. 127-146. http://dx.doi.org/10.52305/ZQKT5678
Capítulo de Livro: Toxoplasma gondii: introduction to life cycle and disease. Toxoplasma gondii prevalence and role in healthy and disease
Nisimura, Lindice Mitie ; Monica, T. C. ; Avila, A.R. 1ed. New york: Nova Science Publisher Inc, 2021.
Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
Ferrarini MG, Nisimura LM, Girard RMBM, Alencar MB, Fragoso MSI, Araújo-Silva CA, Veiga AA, Abud APR, Nardelli SC, Vommaro RC, Silber AM, France-Sagot M, Ávila AR. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis. mSphere. 2021 Jan 6;6(1):e01002-20. doi: 10.1128/mSphere.01002-20.
Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates.
Schappo, A. P. ; Bittencourt, N. C. ; Bertolla, L. P. ; Forcellini, S. ; Silva, A. B. I. E. ; Santos, H. G. ; Gervasio, J. H. ; Lacerda, M. V. ; Lopes, S. C. ; Costa, F. T. ; Albrecht, Letusa . Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates. MEMORIAS DO INSTITUTO OSWALDO CRUZ, v. 116, p. e210227, 2021
Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
Mariana G. Ferrarini, Lindice M. Nisimura, Richard M. B. M. Girard, Mayke B. Alencar, Mariana S. I. Fragoso, Carlla A. Araújo-Silvad, Alan de A. Veigab, Ana Paula R. Abud, Sheila C. Nardelli, Rossiane C. Vommarod, Ariel M. Silber, Marie France-Sagota, Andréa R. Ávila. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis. Therapeutics and Prevention. January/February 2021 Volume 6 Issue 1 e01002-20. https://doi.org/10.1128/mSphere.01002-20
A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients
Catarina Bourgard, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Letusa Albrecht & Fabio T. M. Costa. A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients. Scientific Reports volume 11, Article number: 5089 (2021).
Insights on Rosetting Phenomenon in Plasmodium vivax Malaria
Najara C. Bittencourt, Letícia P. Bertolla & Letusa Albrecht. Insights on Rosetting Phenomenon in Plasmodium vivax Malaria. Parasitology. Current Clinical Microbiology Reports volume 8, pages1–7(2021)
2020
Rosettes integrity protects Plasmodium vivax of being phagocytized
Letusa Albrecht, Stefanie C. P. Lopes, Ana Beatriz L E da Silva, Vanessa Barbosa, Rodrigo P. Almeida, André M. Siqueira, Juliana Almeida Leite, Najara C. Bittencourt, et al., Rosettes integrity protects Plasmodium vivax of being phagocytized. Scientific Reports volume 10, Article number: 16706 (2020).
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response
Bittencourt NC, Silva ABIEd, Virgili NS, Schappo AP, Gervásio JHDB, Pimenta TS, Letusa Albrecht (2020) Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response. PLoS Negl Trop Dis 14(7): e0008471. July 8, 2020. https://doi.org/10.1371/journal.pntd.0008471
Capítulo de livro-Molecular Mechanisms of Toxoplasma gondii Invasion
Thiago Torres de Aguiar and Renato Augusto Da Matta- Universidade Estadual do Norte Fluminense Darcy Ribeiro and
Andréa Rodrigues Ávila– Instituto Carlos Chagas (ICC). Molecular Food Microbiology 12/12/20
2019
Transcription activity contributes to the firing of nonconstitutive origins in African trypanosomes helping to maintain robustness in S-phase duration.
Da Silva, Marcelo S. ; Cayres-silva, Gustavo R. ; Vitarelli, Marcela O. ; Marin, Paula A. ; Hiraiwa, Priscila M. ; Araújo, Christiane B. ; Scholl, Bruno B. ; Ávila, Andrea R. ; Mcculloch, Richard ; Reis, Marcelo S. ; Elias, Maria Carolina . Transcription activity contributes to the firing of nonconstitutive origins in African trypanosomes helping to maintain robustness in S-phase duration. Scientific Reports, v. 9, p. 18512, 2019. doi: 10.1038/s41598-019-54366-w.
A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
Marcele F. Bastos, Letusa Albrecht, Angélica M. Gomes, Stefanie C.P. Lopes et al., A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz Print version ISSN 0074-0276On-line version ISSN 1678-8060 Mem. Inst. Oswaldo Cruz vol.114. June 06, 2019. https://doi.org/10.1590/0074-02760190088
A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
Bastos MF, Albrecht L, Gomes AM, Lopes SC, Vicente CP, de Almeida RP, Cassiano GC, Fonseca RJ, Werneck CC, Pavão MS, Costa FT.A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum.Mem Inst Oswaldo Cruz. 2019;114:e190088. doi: 10.1590/0074-02760190088. Epub 2019 Jun 6.
2018
Fluorescence-based assay for accurate measurement of transcriptional activity in trypanosomatid parasites.
Hiraiwa, P. M. ; De Aguiar, Alessandra Melo ; Ávila, Ar . Fluorescence-based assay for accurate measurement of transcriptional activity in trypanosomatid parasites. CYTOMETRY PART A , v. 93, p. 727-736, 2018. doi: 10.1002/cyto.a.23387.
mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway.
Ávila, Andréa Rodrigues; Cabezas-cruz, Alexjandro ; Gissot, Mathieu . mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway. Parasites & Vectors , v. 11, p. 62, 2018. doi: 10.1186/s13071-018-2648-4.
Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)
Bittencourt NC, Leite JA, Silva ABIE, Pimenta TS, Silva-Filho JL, Cassiano GC, Lopes SCP, Dos-Santos JCK, Bourgard C, Nakaya HI, da Silva Ventura AMR, Lacerda MVG, Ferreira MU Machado RLD, Albrecht L, Costa FTM.. Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).Malar J. 2018 Oct 31;17(1):401. doi: 10.1186/s12936-018-2543-7.
Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria.
Bastos MF, Kayano ACAV, Silva-Filho JL1, Dos-Santos JCK, Judice C1, Blanco YC, Shryock N, Sercundes MK, Ortolan LS, Francelin C, Leite JA, Oliveira R, Elias RM, Câmara NOS, Lopes SCP, Albrecht L, Farias AS, Vicente CP, Werneck CC, Giorgio S, Verinaud L, Epiphanio S, Marinho CRF, Lalwani P, Amino R, Aliberti J, Costa FTM. Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB J. 2018 Aug;32(8):4470-4481. doi: 10.1096/fj.201700844R. Epub 2018 Mar 20.
Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics. Front. Cell. Infect. Microbiol.
Catarina Bourgard, Letusa Albrecht, Ana C. A. V. Kayano, Per Sunnerhagen and Fabio T. M. Costa. Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics. Front. Cell. Infect. Microbiol., 08 February 2018 | https://doi.org/10.3389/fcimb.2018.00034.
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate.
Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri DY, Nosten F, Russell B, Rénia L, Costa FTM. In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malar J. 2018 Jan 10;17(1):20. doi: 10.1186/s12936-017-2144-x.