Publicações
| 2022 | |
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Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial Carmen Lúcia Kuniyoshi Rebelatto1,2,3* , Alexandra Cristina Senegaglia1,2,3, Claudio Luciano Franck2 , Debora Regina Daga1,3, Patrícia Shigunov3,4, Marco Augusto Stimamiglio3,4, Daniela Boscaro Marsaro1,3, Bruna Schaidt1 , Andressa Micosky1 , Ana Paula de Azambuja2 , Cleverson Alex Leitão2 , Ricardo Rasmussen Petterle5 , Valderez Ravaglio Jamur1 , Isadora May Vaz1 , Antônio Paulo Mallmann6 , Hipólito Carraro Junior2 , Eduardo Ditzel7 , Paulo Roberto Slud Brofman1,3† and Alejandro Correa https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935270/pdf/13287_2022_Article_2796.pdf |
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Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related to Early Infantile Epileptic Encephalopathy Ísis V. Biembengut 1 , Patrícia Shigunov 2 , Natalia F. Frota 3,4, Marcos R. Lourenzoni 4 and Tatiana A. C. B. de Souza 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368851/pdf/ijms-23-08708.pdf |
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Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach Sofia Galvão Feronato 1 , Maria Luiza Matos Silva 2 , Rafael Izbicki 2 , Ticiana D. J. Farias 1,3 , Patrícia Shigunov 1 , Bruno Dallagiovanna 1 , Fabio Passetti 1 and Hellen Geremias dos Santos 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410070/pdf/jpm-12-01330.pdf |
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Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells Bruna Cristina Falavinha , 1 María Julia Barisón , 1 Carmen Lúcia Kuniyoshi Rebelatto , 2 Bruna Hilzendeger Marcon , 1 Alessandra de Melo Aguiar , 1 Evelin Brandão da Silva , 1 Marco Augusto Stimamiglio , 1 and Patrícia Shigunov https://downloads.hindawi.com/journals/sci/2022/4930932.pdf |
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Modulation and function of Pumilio proteins in cancer |
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Functionalized Hydrogels for Cartilage Repair: The Value of Secretome-Instructive Signaling María Julia Barisón, Rodrigo Nogoceke, Raphaella Josino, Cintia Delai da Silva Horinouchi , Bruna Hilzendeger Marcon, Alejandro Correa, Marco Augusto Stimamiglio Anny Waloski Robert https://www.mdpi.com/1422-0067/23/11/6010 |
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Proteomics and image screening data of cellular secretomes and their biological effects: Comparing the signals sent by cardiac stromal cells and dermal fibroblasts in culture AnnyWaloskiRoberta MichelBatistabJhonatan BassoLinoaMarco AugustoStimamiglio aAlessandra Melode Aguiar https://www.sciencedirect.com/science/article/pii/S2352340922001743 |
| 2021 | |
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Accessing the Human Pluripotent Stem Cell Translatome by Polysome Profiling Rubens Gomes-Júnior, Patrícia Shigunov, Bruno Dallagiovanna & Isabela Tiemy Pereira https://link.springer.com/protocol/10.1007/7651_2021_437 |
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The impact of blood-processing time on the proteome of human peripheral blood mononuclear cells Bernardo Bonilauri, Marlon DM Santos, Amanda Caroline Camillo-Andrade, Saloê Bispo, Fabio CS Nogueira, Paulo C Carvalho, Nilson IT Zanchin, Juliana de S da G Fischer https://www.sciencedirect.com/science/article/abs/pii/S1570963920302284 |
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The secretome from embryonic stem cell cardiomyogenesis: Same signals, different cellular feedbacks Anny W Robert, Marco A Stimamiglio https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29907 |
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Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation María Julia Barisón, Isabela Tiemy Pereira, Anny Waloski Robert, Bruno Dallagiovanna https://www.mdpi.com/1422-0067/22/3/1330 |
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Using Inhibition of the Adipogenesis of Adipose-Derived Stem Cells In Vitro for Toxicity Prediction Ana Paula Ressetti Abud, Ariane Caroline Campos Paschoal, Crisciele Kuligovski, Rodrigo Rêgo Barros Caruso, Bruno Dallagiovanna, Alessandra Melo de Aguiar https://www.sciencedirect.com/science/article/pii/S2215016121003083 |
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Pluripotent-derived Mesenchymal Stem/stromal Cells: an Overview of the Derivation Protocol Efficacies and the Differences Among the Derived Cells Bruno Moisés de Matos, Anny Waloski Robert, Marco Augusto Stimamiglio, Alejandro Correa https://link.springer.com/article/10.1007/s12015-021-10258-z |
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Genomic surveillance of SARS-CoV-2 in the state of Paraná, Southern Brazil, reveals the cocirculation of the VOC P.1, P.1-like-II lineage and a P.1 cluster harboring the S:E661D mutation Mauro de Medeiros Oliveira, Michelle Orane Schemberger, Andreia Akemi Suzukawa, Irina Nastassja Riediger, Maria do Carmo Debur, Guilherme Becker, Paola Cristina de Medeiros Resende, Tiago Gräf, Eduardo Balsanelli, Valter Antônio de Baura, Emanuel M Souza, Fabio de Oliveira Pedrosa, Lysangela Ronalte Alves, Lucas Blanes, Sheila Cristina Nardeli, Alessandra De Melo Aguiar, Letusa Albrecht, Dalila Zanette, Andréa Ávila, Luis Gustavo Morello, Fabricio Klerynton Marchini, Hellen Geremias dos Santos, Fabio Passetti, Bruno Dallagiovanna, Helisson Faoro https://www.medrxiv.org/content/10.1101/2021.07.14.21260508v1 |
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Combined Use of Tocilizumab and Mesenchymal Stromal Cells in the Treatment of Severe Covid-19: Case Report Alexandra Cristina Senegaglia, Carmen Lúcia Kuniyoshi Rebelatto, Claudio Luciano Franck, Juliana Souza Lima, Lidiane Maria Boldrini-Leite, Debora Regina Daga, Cleverson Alex Leitão, Patrícia Shigunov, Ana Paula de Azambuja, Elisa Bana, Daniela Boscaro Marsaro, Bruna Schaidt, Andressa Micosky, Valderez Ravaglio Jamur, Yara Schluga, Isadora May Vaz, Lisandro Lima Ribeiro, Alejandro Correa, e Paulo Roberto Slud Brofman https://journals.sagepub.com/doi/full/10.1177/09636897211021008 |
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Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features Luciana M Gutiérrez, Matías Valenzuela Alvarez, Yuanzheng Yang, Fiorella Spinelli, María José Cantero, Laura Alaniz, Mariana G García, Eugenie S Kleinerman, Alejandro Correa, Marcela F Bolontrade https://link.springer.com/article/10.1007/s10495-021-01677-x |
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3D Poly (Lactic Acid) Scaffolds Promote Different Behaviors on Endothelial Progenitors and Adipose-Derived Stromal Cells in Comparison With Standard 2D Cultures Giuliana Biagini, Alexandra Cristina Senegaglia, Tarciso Pereira, Lucas Freitas Berti, Bruna Hilzendeger Marcon, Marco Augusto Stimamiglio https://www.frontiersin.org/articles/10.3389/fbioe.2021.700862/full |
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Calcium phosphate-based Bioceramics in the treatment of Osteosarcoma: drug delivery composites and magnetic hyperthermia agentes Tiê Menezes Oliveira, Fernanda Costa Brandão Berti, Sidney Carlos Gasoto, Bertoldo Schneider Jr, Marco Augusto Stimamiglio, Lucas Freitas Berti https://www.frontiersin.org/articles/10.3389/fmedt.2021.700266/full |
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Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders Ísis Venturi Biembengut, Isabelle Leticia Zaboroski Silva, Tatiana de Arruda Campos Brasil de Souza, Patrícia Shigunov https://link.springer.com/article/10.1007/s11033-021-06585-6 |
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Bismuth-based nanoparticles impair adipogenic differentiation of human adipose-derived mesenchymal stem cells Annanda Lyra Ribeiro, Letícia Werzel Bassai, Anny Waloski Robert, Thiago Neves Machado, Arandi Ginana Bezerra Jr., Cintia Delai da Silva Horinouchi, Alessandra Melo de Aguiar https://www.sciencedirect.com/science/article/abs/pii/S0887233321001739?via%3Dihub |
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Methodological Appraisal of Literature Concerning the Analysis of Genetic Variants or Protein Levels of Complement Components on Susceptibility to Infection by Trypanosomatids: A Systematic Review Thais Cristina Tirado1*, Larine Lowry Moura1, Patrícia Shigunov2 and Fabiano Borges Figueiredo1* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656155/pdf/fimmu-12-780810.pdf |
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Combined Use of Tocilizumab and Mesenchymal Stromal Cells in the Treatment of Severe Covid-19: Case Report Ribeiro4 , Alejandro Correa3,5,*, and e Paulo Roberto Slud Brofman1 Alexandra Cristina Senegaglia1,2,3,* , Carmen Lucia Kuniyoshi Rebelatto ´ 1,2,3,*, Claudio Luciano Franck2 , Juliana Souza Lima4 , Lidiane Maria Boldrini-Leite1,3 , Debora Regina Daga1,3, Cleverson Alex Leita˜o2 , Patr´ıcia Shigunov3,5, Ana Paula de Azambuja2 , Elisa Bana4 , Daniela Boscaro Marsaro1,3, Bruna Schaidt1 , Andressa Micosky1 , Valderez Ravaglio Jamur1,3, Yara Schluga2 , Isadora May Vaz1,3, Lisandro Lima,3,* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175829/pdf/10.1177_09636897211021008.pdf |
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Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders Isis Venturi Biembengut1 · Isabelle Leticia Zaboroski Silva1 · Tatiana de Arruda Campos Brasil de Souza1 · Patrícia Shigunov1 https://link.springer.com/content/pdf/10.1007/s11033-021-06585-6.pdf |
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Comparative analysis of the potential of the secretomes of cardiac resident stromal cells and fibroblasts Jhonatan Basso Lino,Anny Waloski Robert,Marco Augusto Stimamiglio,Alessandra Melo de Aguiar https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.2557 |
| 2020 | |
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Recovery of motricity and micturition after transplantation of mesenchymal stem cells in rats subjected to spinal cord injury José Ademar Villanova Junior, Letícia Fracaro, Carmen Lúcia Kuniyoshi Rebelatto, Alexandra Justino da Silva, Fabiane Barchiki, Alexandra Cristina Senegaglia, Alejandro Correa Dominguez, Sérgio Adriane Bezerra de Moura, Cláudia Turra Pimpão, Paulo Roberto Slud Brofman, Rosangela Locatelli Dittrich https://www.sciencedirect.com/science/article/abs/pii/S0304394020304043 |
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USO COMBINADO DE TOCILIZUMABE E CÉLULAS-TRONCO MESENQUIMAIS NO TRATAMENTO DA COVID-19 – RELATO DE CASO AC Senegaglia, CLK Rebelatto, CL Franck, JS Lima, DR Daga, Patricia Shigunov, AP Azambuja, EG Bana, Alejandro C. Dominguez, PRS Brofman https://www.sciencedirect.com/science/article/pii/S2531137920312402?via%3Dihub# |
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Percepção pública sobre a ciência em um evento sobre polularização da ciência em curitiba: paraná Patrícia Shigunov, Paula Renata Fontoura, Wagner Nagib, Bruna Falavinha, Thaisa Kataoka, Rodrigo Pedroso Madlener de Almeida https://www.revistas.ufg.br/rir/article/view/58092 |
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Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach Anny W Robert, Bruna H Marcon, Bruno Dallagiovanna, Patrícia Shigunov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362937/ |
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Polysome-associated lncRNAs during cardiomyogenesis of hESCs |
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Acquisition of stem associated-features on metastatic osteosarcoma cells and their functional effects on mesenchymal stem cells Matías Valenzuela Álvarez, Luciana Gutiérrez, Jerónimo Auzmendi, Alejandro Correa, Alberto Lazarowski, Marcela F Bolontrade https://www.sciencedirect.com/science/article/abs/pii/S030441652030012X |
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Data describing the experimental design and quality control of RNA-Seq of human adipose-derived stem cells undergoing early adipogenesis and osteogenesis Bruna H Marcon, Lucia Spangenberg, Bernardo Bonilauri, Anny Waloski Robert, Addeli Bez Batti Angulski, Guillermo Cabrera Cabo, Axel R Cofré, Paulo Sergio Loiacono Bettes, Bruno Dallagiovanna, Patrícia Shigunov https://www.sciencedirect.com/science/article/pii/S235234091931409X |
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Secretome Analysis Performed During in vitro Cardiac Differentiation: Discovering the Cardiac Microenvironment Anny Waloski Robert, Isabela Tiemy Pereira, Bruno Dallagiovanna, Marco Augusto Stimamiglio https://www.frontiersin.org/articles/10.3389/fcell.2020.00049/full |
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Dose-dependent cell necrosis induced by silica nanoparticles Thamile Luciane Reus, Bruna Hilzendeger Marcon, Ariane Caroline Campos Paschoal, Iris Renata Sousa Ribeiro, Mateus Borba Cardoso, Bruno Dallagiovanna, Alessandra Melo de Aguiar https://www.sciencedirect.com/science/article/abs/pii/S0887233319304709 |
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DDX6 Helicase Behavior and Protein Partners in Human Adipose Tissue-Derived Stem Cells during Early Adipogenesis and Osteogenesis Bruna Hilzendeger Marcon, Carmen K Rebelatto, Axel R Cofré, Bruno Dallagiovanna, Alejandro Correa https://www.mdpi.com/1422-0067/21/7/2607 |
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The Expression Profile of Dental Pulp-Derived Stromal Cells Supports Their Limited Capacity to Differentiate into Adipogenic Cells Letícia Fracaro, Alexandra C Senegaglia, Roberto H Herai, Amanda Leitolis, Lidiane M Boldrini-Leite, Carmen LK Rebelatto, Paul J Travers, Paulo RS Brofman, Alejandro Correa https://www.mdpi.com/1422-0067/21/8/2753 |
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Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture Isabelle Leticia Zaboroski Silva, Anny Waloski Robert, Guillermo Cabrera Cabo, Lucia Spangenberg, Marco Augusto Stimamiglio, Bruno Dallagiovanna, Daniela Fiori Gradia, Patrícia Shigunov https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222373 |
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Linking long noncoding RNAs (lncRNAs) and doping detection Bernardo Bonilauri, Bruno Dallagiovanna https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.2952?af=R |
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Long Non-coding RNAs Are Differentially Expressed After Different Exercise Training Programs Bernardo Bonilauri, Bruno Dallagiovanna https://www.frontiersin.org/articles/10.3389/fphys.2020.567614/full |
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Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells Cintia DS Horinouchi, María Julia Barisón, Anny W Robert, Crisciele Kuligovski, Alessandra M Aguiar, and Bruno Dallagiovanna https://www.wjgnet.com/1948-0210/full/v12/i12/1640.htm |
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The secretome from embryonic stem cell cardiomyogenesis: Same signals, different cellular feedbacks Anny W Robert, Marco A Stimamiglio |
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Linking long noncoding RNAs (lncRNAs) and doping detection Bernardo Bonilauri, Bruno Dallagiovanna |
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Long Non-coding RNAs Are Differentially Expressed After Different Exercise Training Programs Bernardo Bonilauri, Bruno Dallagiovanna |
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Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach Anny W Robert, Bruna H Marcon, Bruno Dallagiovanna, Patrícia Shigunov |
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DDX6 Helicase Behavior and Protein Partners in Human Adipose Tissue-Derived Stem Cells during Early Adipogenesis and Osteogenesis |
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The Expression Profile of Dental Pulp-Derived Stromal Cells Supports Their Limited Capacity to Differentiate into Adipogenic Cells Letícia Fracaro, Alexandra C Senegaglia, Roberto H Herai, Amanda Leitolis, Lidiane M Boldrini-Leite, Carmen LK Rebelatto, Paul J Travers, Paulo RS Brofman, Alejandro Correa |
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Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture Isabelle Leticia Zaboroski Silva, Anny Waloski Robert, Guillermo Cabrera Cabo, Lucia Spangenberg, Marco Augusto Stimamiglio, Bruno Dallagiovanna, Daniela Fiori Gradia, Patrícia Shigunov |
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Dose-dependent cell necrosis induced by silica nanoparticles |
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Secretome Analysis Performed During in vitro Cardiac Differentiation: Discovering the Cardiac Microenvironment
Anny Waloski Robert, Isabela Tiemy Pereira, Bruno Dallagiovanna, Marco Augusto Stimamiglio |
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Data describing the experimental design and quality control of RNA-Seq of human adipose-derived stem cells undergoing early adipogenesis and osteogenesis
Bruna H Marcon, Lucia Spangenberg, Bernardo Bonilauri, Anny Waloski Robert, Addeli Bez Batti Angulski, Guillermo Cabrera Cabo, Axel R Cofré, Paulo Sergio Loiacono Bettes, Bruno Dallagiovanna, Patrícia Shigunov |
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Acquisition of stem associated-features on metastatic osteosarcoma cells and their functional effects on mesenchymal stem cells
Matías Valenzuela Álvarez, Luciana Gutiérrez, Jerónimo Auzmendi, Alejandro Correa, Alberto Lazarowski, Marcela F Bolontrade |
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Polysome-associated lncRNAs during cardiomyogenesis of hESCs
Isabela Tiemy Pereira, Lucia Spangenberg, Guillermo Cabrera, Bruno Dallagiovanna |
2019 |
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Human Heart Explant-Derived Extracellular Vesicles: Characterization and Effects on the In VitroRecellularization of Decellularized Heart Valves. |
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Structural assessments in decellularized extracellular matrix of porcine semilunar heart valves: Evaluation of cell niches. Roderjan JG1, de Noronha L2, Stimamiglio MA3, Correa A3, Leitolis A3, Bueno RRL4, da Costa FDA5. |
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The skin regeneration potential of a pro-angiogenic secretome from human skin-derivedmultipotent stromal cells. Robert AW1, Azevedo Gomes F2, Rode MP2, Marques da Silva M2, Veleirinho MBDR2, Maraschin M2, Hayashi L2, Wosgrau Calloni G2, Stimamiglio MA1. |
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Cardiomyogenic differentiation is fine-tuned by differential mRNA association with polysomes. Pereira IT1, Spangenberg L2, Robert AW1, Amorín R2, Stimamiglio MA1, Naya H2, Dallagiovanna B3. |
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Cell cycle genes are downregulated after adipogenic triggering in human adipose tissue-derived stem cells by regulation of mRNA abundance Bruna H. Marcon, Patrícia Shigunov, Lucia Spangenberg, Isabela Tiemy Pereira, Alessandra Melo de Aguiar, Rocío Amorín, Carmen K. Rebelatto, Alejandro Correa & Bruno Dallagiovanna |
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The inhibition of adipogenesis via an in vitro assay can reduce animal use by more precisely estimating the starting dose for the acute toxic class method Ana Paula RessettAbudaCriscieleKuligovskiaNatássia Caroline ResendeCorrêaa1Elizabeth Cunha Pennade MoraesabRodrigo Rêgo BarrosCarusoacDesirée CigaranSchuckdCarla AbdoBrohemdBrunoDallagiovannaaAlessandra Melode Aguiara |
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Cardiomyogenesis Modeling Using Pluripotent Stem Cells: The Role of Microenvironmental Signaling Amanda Leitolis*†, Anny W. Robert*†, Isabela T. Pereira*†, Alejandro Correa and Marco A. Stimamiglio |
| 2018 |
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In vitro evaluation of bovine pericardium after a soft decellularization approach for use in tissueengineering.
Heuschkel MA1, Leitolis A1, Roderjan JG2, Suss PH2, Luzia CAO2, da Costa FDA2, Correa A1, Stimamiglio MA1. |
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Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats afterSevere Myocardial Infarction.
Correa A1, Ottoboni GS2, Senegaglia AC2, Capriglione LGA2, Miyague NI2, Leite LMB2, Jamur VR2, Rebelatto CLK2, Olandoski M2, Brofman PRS2 |
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Gene expression analysis of human adipose tissue-derived stem cells during the initial steps of in vitro osteogenesis.
Robert AW1, Angulski ABB1, Spangenberg L2, Shigunov P1, Pereira IT1, Bettes PSL3, Naya H2, Correa A1, Dallagiovanna B1, Stimamiglio MA4. |
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Human T Lymphocytes Are Permissive for Dengue Virus Replication. |
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Perspectivas e desafios regulatórios no uso de células-tronco em métodos alternativos ao uso de animais
Cintia Delai da Silva Horinouchi ,Ana Paula Ressetti Abud ,Ariane Caroline Paschoal, Crisciele Kuligosviski, Thamile Luciane Reus, Bruno Dallagiovanna Muniz, Alessandra Melo de Aguiar
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Polysome profiling followed by RNA-seq of cardiac differentiation stages in hESCs.
Pereira IT1, Spangenberg L2, Robert AW1, Amorín R2, Stimamiglio MA1, Naya H2, Dallagiovanna B1. |
| 2017 |
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Mesenchymal Stem/Stromal Cells as Biological Factories |
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Internal control for realtime polymerase chain reaction based on MS2 bacteriophage for RNAviruses diagnostics. |
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The Protein Content of Extracellular Vesicles Derived from Expanded Human Umbilical CordBlood-Derived CD133+ and Human Bone Marrow-Derived Mesenchymal Stem Cells PartiallyExplains Why both Sources are Advantageous for Regenerative Medicine.
Angulski AB1, Capriglione LG2, Batista M1, Marcon BH1, Senegaglia AC2, Stimamiglio MA3, Correa A4. |
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Tissue Derived Signals for Mesenchymal Stem Cell Stimulation: Role of Cardiac and UmbilicalCord Microenvironments.
Robert AW1, Schittini AV, Marchini FK, Batista M, Affonso Da Costa MB, Senegaglia AC, Brofman PR, Abud AP, Stimamiglio MA. |
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lncRNAs are associated with polysomes during adipose-derived stem cell differentiation.
Dallagiovanna B1, Pereira IT2, Origa-Alves AC3, Shigunov P4, Naya H5, Spangenberg L6. |
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Downregulation of the protein synthesis machinery is a major regulatory event during earlyadipogenic differentiation of human adipose-derived stromal cells.
Marcon BH1, Holetz FB1, Eastman G2, Origa-Alves AC1, Amorós MA3, de Aguiar AM1, Rebelatto CK4, Brofman PRS4, Sotelo-Silveira J5, Dallagiovanna B6 |
| 2016 | |
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Secretome from resident cardiac stromal cells stimulates proliferation, cardiomyogenesis and angiogenesis of progenitor cells. |