Publicações recentes

Camillo Dos Santos LP, de Matos BM, de Maman Ribeiro BC, Zanchin NIT, Guimarães BG. Crystal structure of the MIF4G domain of the Trypanosoma cruzi translation initiation factor EIF4G5. Acta Crystallogr F Struct Biol Commun. 2019 Dec 1;75(Pt 12):738-743. doi: 10.1107/S2053230X19015061.

Rodrigues EC, Mörking P, Rosa JO, Romagnoli BAA, Guimarães BG, Hiraiwa PM, Klinke A, de Aguiar AM, Kuligovski C, Goldenberg S, Ramos ASP. TcNST2 encodes a Golgi-localized UDP-galactose transporter in Trypanosoma cruzi. Parasitology. 2019 Sep;146(11):1379-1386. doi: 10.1017/S0031182019000738.

Stein RJ, Duarte GL, Scheunemann L, Spohr MG, de Araújo Júnior AT, Ricachenevsky FK, Rosa LMG, Zanchin NIT, Dos Santos RP, Fett JP. Genotype Variation in Rice (Oryza sativa L.) Tolerance to Fe Toxicity Might Be Linked to Root Cell Wall Lignification. Front Plant Sci. 2019 Jun 12;10:746. doi: 10.3389/fpls.2019.00746.

Leony LM, Freitas NEM, Del-Rei RP, Carneiro CM, Reis AB, Jansen AM, Xavier SCC, Gomes YM, Silva ED, Reis MG, Fraga DBM, Celedon PAF, Zanchin NIT, Dantas-Torres F, Santos FLN. Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. PLoS Negl Trop Dis. 2019 Jun 26;13(6):e0007545. doi: 10.1371/journal.pntd.0007545.

Reolon LW, Vichier-Guerre S, de Matos BM, Dugué L, Assunção TRDS, Zanchin NIT, Pochet S, Guimarães BG. Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4. Nucleic Acids Res. 2019 May 8. pii: gkz339. doi: 10.1093/nar/gkz339.

Cesaro G, Carneiro FRG, Ávila AR, Zanchin NIT, Guimarães BG. Trypanosoma brucei RRP44 is involved in an early stage of large ribosomal subunit RNA maturation. RNA Biol. 2019 Jan;16(1):133-143. doi: 10.1080/15476286.2018.1564463.

Del-Rei RP, Leony LM, Celedon PAF, Zanchin NIT, Reis MGD, Gomes YM, Schijman AG, Longhi SA, Santos FLN. Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries. PLoS One. 2019 Apr 18;14(4):e0215623. doi: 10.1371/journal.pone.0215623.

Dopico E, Del-Rei RP, Espinoza B, Ubillos I, Zanchin NIT, Sulleiro E, Moure Z, Celedon PAF, Souza WV, da Silva ED, Gomes YM, Santos FLN. Immune reactivity to Trypanosoma cruzi chimeric proteins for Chagas disease diagnosis in immigrants living in a non-endemic setting. BMC Infect Dis. 2019 Mar 12;19(1):251. doi: 10.1186/s12879-019-3872-z.

Dos Santos Rodrigues FH, Firczuk H, Breeze AL, Cameron AD, Walko M, Wilson AJ, Zanchin NIT, McCarthy JEG. The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs. Nucleic Acids Res. 2018 Nov 22. doi: 10.1093/nar/gky1187.

Santos FLN, Campos ACP, Amorim LDAF, Silva ED, Zanchin NIT, Celedon PAF, Del-Rei RP, Krieger MA, Gomes YM. Highly Accurate Chimeric Proteins for the Serological Diagnosis of Chronic Chagas Disease: A Latent Class Analysis. Am J Trop Med Hyg. 2018 Nov;99(5):1174-1179. doi: 10.4269/ajtmh.17-0727.

Hiraiwa PM, de Aguiar AM, Ávila AR. Fluorescence-based assay for accurate measurement of transcriptional activity in trypanosomatid parasites. Cytometry A. 2018 Jul;93(7):727-736.

Alcantara MV, Kessler RL, Gonçalves REG, Marliére NP, Guarneri AA, Picchi GFA, Fragoso SP. Knockout of the CCCH zinc finger protein TcZC3H31 blocks Trypanosoma cruzi differentiation into the infective metacyclic form. Mol Biochem Parasitol. 2018 Apr;221:1-9.

Romagnoli BAA, Picchi GFA, Hiraiwa PM, Borges BS, Alves LR, Goldenberg S. Improvements in the CRISPR/Cas9 system for high efficiency gene disruption in Trypanosoma cruzi. Acta Trop. 2018 Feb;178:190-195.

Nunes HF, Ananina G, Costa VP, Zanchin NIT, de Vasconcellos JPC, de Melo MB. Investigation of CAV1/CAV2 rs4236601 and CDKN2B-AS1 rs2157719 in primary open-angle glaucoma patients from Brazil. Ophthalmic Genet. 2018 Apr;39(2):194-199.

Contreras Lancheros CA, Pelegrino MT, Kian D, Tavares ER, Hiraiwa PM, Goldenberg S, Nakamura CV, Yamauchi LM, Pinge-Filho P, Seabra AB, Yamada-Ogatta SF. Selective Antiprotozoal Activity of Nitric Oxide-releasing Chitosan Nanoparticles Against Trypanosoma cruzi: Toxicity and Mechanisms of Action. Curr Pharm Des. 2018;24(7):830-839.

Moraes L, Zanchin NIT, Cerutti JM.  ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway. Oncotarget. 2017 Jun 29;8(40):67769-67781.

Souza C, Zanchin NI, Krieger MA, Ludwig A. In silico analysis of amino acid variation in human respiratory syncytial virus: insights into immunodiagnostics. Mem Inst Oswaldo Cruz. 2017 Oct;112(10):655-663.

Janissen R, Sahoo PK, Santos CA, da Silva AM, von Zuben AAG, Souto DEP, Costa ADT, Celedon P, Zanchin NIT, Almeida DB, Oliveira DS, Kubota LT, Cesar CL, Souza AP, Cotta MA. InP Nanowire Biosensor with Tailored Biofunctionalization: Ultrasensitive and Highly Selective Disease Biomarker Detection. Nano Lett. 2017 Oct 11;17(10):5938-5949.

Santos FLN, Celedon PAF, Zanchin NIT, Leitolis A, Crestani S, Foti L, de Souza WV, Gomes YM, Krieger MA. Performance Assessment of a Trypanosoma cruzi Chimeric Antigen in Multiplex Liquid Microarray Assays. J Clin Microbiol. 2017 Oct;55(10):2934-2945.

Santos FL, Celedon PA, Zanchin NI, Souza WV, da Silva ED, Foti L, Krieger MA, Gomes YM. Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study. PLoS Negl Trop Dis. 2017 Mar 8;11(3):e0005433.

Santana AG, Gracher AH, Rüdiger AL, Zanchin NI, Carvalho PC, Cipriani TR, de Arruda Campos Brasil de Souza T. Identification of potential targets for an anticoagulant pectin. J Proteomics. 2017 Jan 16;151:243-250.

Picchi GF, Zulkievicz V, Krieger MA, Zanchin NT, Goldenberg S, de Godoy LM. Post-translational Modifications of Trypanosoma cruzi Canonical and Variant Histones. J Proteome Res. 2017 Mar 3;16(3):1167-1179.

Bittencourt IA, Serpeloni M, Hiraiwa PM, de Arruda Campos Brasil de Souza T, Ávila AR. Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi. Int J Biol Macromol. 2017 May;98:793-801.

de Aquino PF, Carvalho PC, Nogueira FC, da Fonseca CO, de Souza Silva JC, Carvalho Mda G, Domont GB, Zanchin NI, Fischer Jde S. A Time-Based and Intratumoral Proteomic Assessment of a Recurrent Glioblastoma Multiforme. Front Oncol. 2016 Aug 22;6:183.

Santos FL, Celedon PA, Zanchin NI, Brasil Tde A, Foti L, Souza WV, Silva ED, Gomes Yde M, Krieger MA.Performance Assessment of Four Chimeric Trypanosoma cruzi Antigens Based on Antigen-Antibody Detection for Diagnosis of Chronic Chagas Disease. PLoS One. 2016 Aug 12;11(8):e0161100.

Scorsato V, Lima TB, Righetto GL, Zanchin NI, Brandão-Neto J, Sandy J, Pereira HD, Ferrari ÁJ, Gozzo FC, Smetana JH, Aparicio R. Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus. Sci Rep. 2016 Aug 4;6:30813.

Lopes ALK, Cardoso J, Dos Santos FRCC, Silva ACG, Stets MI, Zanchin NIT, Soares MJ, Krieger MA. Development of a magnetic separation method to capture sepsis associated bacteria in blood. J Microbiol Methods. 2016 Sep;128:96-101.

Silveira GF, Strottmann DM, de Borba L, Mansur DS, Zanchin NI, Bordignon J, dos Santos CN. Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I interferon response. Clin Exp Immunol. 2016 Jan;183(1):114-28.

Gaullier G, Miron S, Pisano S, Buisson R, Le Bihan YV, Tellier-Lebègue C, Messaoud W, Roblin P, Guimarães BG, Thai R, Giraud-Panis MJ, Gilson E, Le Du MH. A higher-order entity formed by the flexible assembly of RAP1 with TRF2.Nucleic Acids Res. 2016 Feb 29;44(4):1962-76.

Bou-Nader C, Pecqueur L, Bregeon D, Kamah A, Guérineau V, Golinelli-Pimpaneau B, Guimarães BG, Fontecave M, Hamdane D. An extended dsRBD is required for post-transcriptional modification in human tRNAs. Nucleic Acids Res. 2015 Oct 30;43(19):9446-56.

El Sahili A, Li SZ, Lang J, Virus C, Planamente S, Ahmar M, Guimaraes BG, Aumont-Nicaise M, Vigouroux A, Soulère L, Reader J, Queneau Y, Faure D, Moréra S. A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens. PLoS Pathog. 2015 Aug 5;11(8):e1005071.

Klinke S, Foos N, Rinaldi JJ, Paris G, Goldbaum FA, Legrand P, Guimarães BG, Thompson A. S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1433-43.

Silveira AB, Laranjeira AB, Rodrigues GO, Leal PC, Cardoso BA, Barata JT, Yunes RA, Zanchin NI, Brandalise SR, Yunes JA. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. Oncotarget. 2015 May 30;6(15):13105-18.

Fischer JSDG, Dos Santos MDM, Marchini FK, Barbosa VC, Carvalho PC, Zanchin NIT. A scoring model for phosphopeptide site localization and its impact on the question of whether to use MSA. J Proteomics. 2015 Nov 3;129:42-50.

Inoue AH, Serpeloni M, Hiraiwa PM, Yamada-Ogatta SF, Muniz JR, Motta MC, Vidal NM, Goldenberg S, Avila AR. Identification of a novel nucleocytoplasmic shuttling RNA helicase of trypanosomes. PLoS One. 2014 Oct 14;9(10):e109521.

Klinke S, Otero LH, Rinaldi J, Sosa S, Guimarães BG, Shepard WE, Goldbaum FA, Bonomi HR. Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris. Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1636-9.

Nawrotek A, Guimarães BG, Velours C, Subtil A, Knossow M, Gigant B. Biochemical and structural insights into microtubule perturbation by CopN from Chlamydia pneumoniae. J Biol Chem. 2014 Sep 5;289(36):25199-210.

Serer MI, Bonomi HR, Guimarães BG, Rossi RC, Goldbaum FA, Klinke S. Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility. Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1419-34.

Guimarães BG, Hamdane D, Lechauve C, Marden MC, Golinelli-Pimpaneau B. The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1005-14.

Barbosa RL, Legrand P, Wien F, Pineau B, Thompson A, Guimarães BG. RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. PLoS One. 2014 Feb 18;9(2):e89138.

Alcantara MV, Fragoso SP, Picchi GF. Knockout confirmation for Hurries: rapid genotype identification of Trypanosoma cruzi transfectants by polymerase chain reaction directly from liquid culture. Mem Inst Oswaldo Cruz. 2014 Jul;109(4):511-3.

Lorencini M, Brohem CA, Dieamant GC, Zanchin NI, Maibach HI. Active ingredients against human epidermal aging. Ageing Res Rev. 2014 May;15:100-15.